idiopathic anaphylaxis information center

a resource for people with ia and other mast cell disorders

Anaphylaxis: Allergens

Yes, Virginia, you might be allergic to that, too!

This page lists some of the many substances that have elicited human anaphylaxis. Click on a category to open or close it. Hover over an item to reveal a relevant reference, or click it to go to the complete citation in the References pages, which will include a link to the article, if it is freely available on the Internet.



Biologic substances (human)


Contrast media

Drug additives (excipients)


Food additives


Baked beans [Zacharisen MC, Kurup V. Anaphylaxis to beans. J Allergy Clin Immunol. 1998; 101:556–7.]

Buckwheat [Heffler E, Guida G, Badiu I, Nebiolo F, Rolla G. Anaphylaxis after eating Italian pizza containing buckwheat as the hidden food allergen. J Investig Allergol Clin Immunol. 2007; 17:261–3.] (in pizza dough)

Cabbage [Blaiss MS, McCants ML, Lehrer SB. Anaphylaxis to cabbage: detection of allergens. Ann Allergy. 1987; 58:248–50.]

Cassava [Ibero M, Castillo MJ, Pineda F. Allergy to cassava: A new allergenic food with cross-reactivity to latex. J Investig Allergol Clin Immunol. 2007;17(6):409-12.]

Chicken soup [Saff RH, Fink JN. Anaphylaxis to chicken soup: a case report and a brief history of the chicken in medicine. J Allergy Clin Immunol. 1992; 89:1061–2]

Egg [Liew WK, Williamson E, Tang MLK. Anaphylaxis fatalities and admissions in Australia. J Allergy Clin Immunol. 2009; 123:434–42.] (reported as far back as the 16th and 17th centuries Cianferoni A, Spergel JM. Food allergy: review, classification and diagnosis. Allergol Int. 2009; 58:457–66.)

Ethanol [Mallon DF, Katelaris CH. Ethanol-induced anaphylaxis following ingestion of overripe rock melon, Cucumis melo. Ann Allergy Asthma Immunol. 1997; 78:285–6.] (from overripe melon)

Garlic [Vovolis V, Kalogiros L, Ivanova D, Koutsostathis N. Garlic-induced severe anaphylaxis in a nonatopic patient. J Investig Allergol Clin Immunol. 2010; 20:356.]

Kangaroo meat [Boyle RJ, Russo VC, et al. Anaphylaxis to kangaroo meat: identification of a new marsupial allergen. Allergy. 2007; 62:209–11.]

Lamb meat [Welt K, Hinrichs R, Ott S, Thalmann M, Dieckmannken J, et al. Anaphylaxis after the ingestion of lamb meat. Allergy. 2005; 60:545.]

Lettuce [Bascones O, Rodríguez-Pérez R, Juste S, Moneo I, Caballero M. Lettuce-Induced Anaphylaxis. Identification of the Allergen Involved. J Investig Allergol Clin Immunol. 2009;19(2):154-7.]

Limpet [Carrillo T, Rodriguez de Castro F, et al. Anaphylaxis due to limpet ingestion. Ann Allergy. 1994; 73:504–8.] (sea mollusk)

Lychee [Raap U, Schaefer T, Kapp A, Wedi B. Exotic food allergy: anaphylactic reaction to lychee. J Investig Allergol Clin Immunol. 2007;17(3):199–201.]

Mango [Hegde VL, Venkatesh YP. Anaphylaxis following ingestion of mango fruit. J Investig Allergol Clin Immunol. 2007; 17:341–4.]

Matsutake mushrooms [Toda T, Yamaguchi M, Nakase Y, Sugimoto N, Suzukawa M, Nagase H, et al. A case of anaphylactic reaction following Matsutake mushroom ingestion: Demonstration of histamine release reaction of basophils. Allergol Int. 2010;59:4.]

Millet [Stuck BA, Blum A, Klimek L, Hörmann K. Millet, a potentially life-threatening allergen. Allergy. APR 2001; 56(4):350.]

Onion [Arena A, Cislaghi C, Falagiani P. Anaphylactic reaction to the ingestion of raw onion. A case report. Allergol Immunopathol (Madr). 2000;28(5):287–9.]

Pancakes [Wen DC, Shyur SD, Ho CM, Chiang YC, Huang LH, Lin MT, et al. Systemic anaphylaxis after the ingestion of pancake contaminated with the storage mite Blomia freemani. Ann Allergy Asthma Immunol 2005; 95:612–4.] (mite-infested pancake mix)

Peanut oil [Cantani A. Anaphylaxis from peanut oil in infant feedings and medications. Eur Rev Med Pharmacol Sci. 1998; 2:203–6.] (in infant food and medications)

Peas [Wensing M, Knulst AC, Piersma S, O'Kane F, Knol EF, Koppelman SJ. Patients with anaphylaxis to pea can have peanut allergy caused by cross-reactive IgE to vicilin (Ara h 1). J Allergy Clin Immunol. 2003; 111:420–4.]

Potato [Beausoleil JL, Spergel JM, Pawlowski NA. Anaphylaxis to raw potato. Ann Allergy Asthma Immunol. 2001; 86:68-70.] (raw)

Pumpkin [La Shell MS, Otto HF, Whisman BA, et al. Allergy to pumpkin and cross-reactivity to pollens and other foods. Ann Allergy Asthma Immunol. 2010; 104(2):178–180.] (both flesh and seeds)

Quail egg [Alessandri C, Calvani M, Jr., et al. Anaphylaxis to quail egg. Allergy. 2005; 60:128–9.]

Razor shell [Martin-Garcia C, Carnes J, Blanco R, Martinez-Alonso JC, Callejo-Melgosa A, Frades A, et al. Selective hypersensitivity to boiled razor shell. J Investig Allergol Clin Immunol. 2007;17(4):271–3.] (a mollusk)

Red currants [Zollner TM, Schmidt P, et al. Anaphylaxis to red currants. Allergy. 2000; 55:511.]

Red meat [Commins SP, Satinover SM, Hosen J, Mozena J, Borish L, Lewis BD, et al. Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-alpha-1,3-galactose. J Allergy Clin Immunol. 2009;123(2):426-33.]

Red yeast rice [Wigger-Alberti W, Bauer A, et al. Anaphylaxis due to Monascus purpureus-fermented rice (red yeast rice). Allergy. 1999; 54:1330–1] (produced by fermentation of washed, cooked, nonglutinous rice by the fungus, M. purpureus; a traditional East Asian food)

Seafood [Lopata AL, Lehrer SB. New insights into seafood allergy. Curr Opin Allergy Clin Immunol. 2009;9(3):270–7.]

Sea urchin roe [Hickey RW. Sea urchin roe (uni) anaphylaxis. Ann Allergy Asthma Immunol. 2007; 98:493–4.]

Soy beans, fermented [Inomata N, Osuna H, Yanagimachi M, Ikezawa Z. Late-onset anaphylaxis to fermented soybeans: the first confirmation of food-induced, late-onset anaphylaxis by provocation test. Ann Allergy Asthma Immunol. 2005; 94:402–6.]

Wheat flour [Zapatero L, Martinez MI, et al. Oral wheat flour anaphylaxis related to wheat alpha-amylase inhibitor subunits CM3 and CM16. Allergy. 2003; 58:956.]

Yacon [Yun EY, Kim HS, Kim YE, et al. A case of anaphylaxis after the ingestion of yacon. Allergy Asthma Immunol Res. 2010; 2:149–52.] (Smallanthus sonchifolius, native to South America, is a perennial bulbous plant with edible roots)

Herbs and supplements

Insects and parasites


Medications — Anesthesia

Medications — Antibacterials and antibiotics

Medications — Monoclonal and humanized antibodies

Medications — Pain

Acetaminophen [Schwarz N, Ham Pong A. Acetaminophen anaphylaxis with aspirin and sodium salicylate sensitivity: a case report. Ann Allergy Asthma Immunol. 1996; 77:473-4.] (brand names include: Tylenol® and Anacin AF)

Aspirin and other NSAIDs [Szczeklik A. Analgesics. Chemical Immunol & Allergy. 2010; 95:170-9.] (non-steroidal anti-inflammatory drugs)

Celecoxib [Levy MB, Fink JN. Anaphylaxis to celecoxib. Ann Allergy Asthma Immunol. 2001;87(1):72–3.] (NSAID, selective COX-2 inhibitor, brand name: Celebrex®)

Diclofenac potassium [Cakar MA, Gunduz H, et al. Acute coronary syndrome due to diclofenac potassium induced anaphylaxis: two Kounis syndrome variants in the same patient. Anadolu Kardiyol Derg. 2011; 11:88–9.] (NSAID, chemical name: 2-[(2,6-dichlorophenyl)amino] benzeneacetic acid, monopotassium salt)

Ibuprofen [Kang LW, Kidon MI, et al. Severe anaphylactic reaction to ibuprofen in a child with recurrent urticaria. Pediatrics. 2007;120(3):e742-4.] (NSAID, brand names: Addaprin, Advil®, Midol Cramps & Bodyaches, Motrin, Nuprin, Tab-Profen, Ultraprin, Uni-Pro, Wal-Profen)

Naproxen [Ross JE. Naproxen-induced anaphylaxis. A case report. Am J Forensic Med Pathol. 1994;15(2):180–1.] (NSAID, brand names: Aleve®, Naprosyn, Aflaxen, Anaprox, Midol® Extended Relief)

Steroids and/or local anesthetics [Wagner AL. Anaphylaxis after steroid and local anesthetic injections. AJNR Am J Neuroradiol. 2000; 21:1977–8.], via injection

Tolmetin [Rossi AC, Knapp DE. Tolmetin-Induced anaphylactoid reactions. N Engl Journal Med. 1982;307(8):499–500.] (NSAID, brand name: Tolectin)

Zomepirac sodium [Samuel SA. Apparent anaphylactic reaction to zomepirac (Zomax). N Engl J Med. 1981;304(16):978.] (NSAID, brand name: Zomax)

Medications — Vaccines

Hepatitis A (HAV) and hepatitis B (HBV) vaccines [Johann-Liang R, Josephs S, Dreskin SC. Analysis of anaphylaxis cases after vaccination: 10-year review from the national vaccine injury compensation program. Ann Allergy Asthma Immunol. 2011; 106:440–3.]

Human papillomavirus vaccine [Brotherton JM, Gold MS, et al. Anaphylaxis following quadrivalent human papillomavirus vaccination. CMAJ. 2008; 179:525–33.]

Inactivated polio vaccine (IPV) [Johann-Liang R, Josephs S, Dreskin SC. Analysis of anaphylaxis cases after vaccination: 10-year review from the national vaccine injury compensation program. Ann Allergy Asthma Immunol. 2011; 106:440–3.]

Influenza vaccine [Johann-Liang R, Josephs S, Dreskin SC. Analysis of anaphylaxis cases after vaccination: 10-year review from the national vaccine injury compensation program. Ann Allergy Asthma Immunol. 2011; 106:440–3.]

Measles, mumps and rubella vaccine (MMR) [Johann-Liang R, Josephs S, Dreskin SC. Analysis of anaphylaxis cases after vaccination: 10-year review from the national vaccine injury compensation program. Ann Allergy Asthma Immunol. 2011; 106:440–3.]

Meningococcal vaccines (MCV4, MPSV) [Maglione MA, Lopamudra d, Raaen L, et al. Safety of vaccines used for routine immunization of US children: A systematic review. Pediatrics. 2014; 134(2):1–13.]

Tetanus-diphtheria vaccine (Td) and diphtheria and tentanus toxoids with acellular pertussis (DTaP) [Johann-Liang R, Josephs S, Dreskin SC. Analysis of anaphylaxis cases after vaccination: 10-year review from the national vaccine injury compensation program. Ann Allergy Asthma Immunol. 2011; 106:440–3.]

Varicella vaccine [Maglione MA, Lopamudra d, Raaen L, et al. Safety of vaccines used for routine immunization of US children: A systematic review. Pediatrics. 2014; 134(2):1–13.]

Yellow fever vaccine [Kelso JM, Mootrey GT, Tsai TF. Anaphylaxis from yellow fever vaccine. J Allergy Clin Immunol. 1999; 103:698–701.]

Medications — Others

Beta blockers [Arkinstall WW. Beta-blocker therapy and the risk of anaphylaxis. Cmaj 1987; 137:370-1.] (also called beta-adrenergic blocking agents, block norepinephrine and epinephrine from binding to the beta receptors on nerves; used to reduce heart rate and blood pressure, to treat abnormal heart rhythm, hypertension, heart failure, angina, pheochromocytoma, and to prevent migraines)

Cetirizine [Afonso N, Shetgaonkar P, Dang A, Rataboli PV. Cetirizine-induced anaphylaxis: a rare adverse drug reaction. Br J Clin Pharmacol. 2009;67(5):577–8.] (H1 antihistamine; brand name: Zyrtec®)

Cromolyn sodium [Ahmad S. Cromolyn sodium and anaphylaxis. Ann Intern Med. 1983;99(6):882.] (mast cell-stabilizing medication; brand name: Gastrocrom®)

Dextran 70 [Fanous LH, Gray A, Felmingham J. Severe anaphylactoid reactions to dextran 70. Br Med J. 1977; 2:1189–90.] (high molecular weight plasma volume expander derived from natural sources of sugar)

Disodium cromoglycate [Ibanez MD, Laso MT, Martinez-San Irineo M, Alonso E. Anaphylaxis to disodium cromoglycate. Ann Allergy Asthma Immunol. 1996; 77:185–6.] (inhaled asthma medication)

Famotidine [Kim YI, Park CK, et al. A case of famotidine-induced anaphylaxis. J Investig Allergol Clin Immunol. 2010; 20:166–9.] (H2 antihistamine; brand names: Pepcid®, Fluxid, Mylanta® AR)

Hydrocortisone injection [Chan CS, Brown IG, et al. Hydrocortisone-induced anaphylaxis. Med J Aust 1984; 141:444–6.]

Lansoprazole [Demirkan K, Bozkurt B, Karakaya G, Kalyoncu AF. Anaphylactic reaction to drugs commonly used for gastrointestinal system diseases: 3 case reports and review of the literature. J Investig Allergol Clin Immunol. 2006; 16:203–9.] (brand name: Prevacid®; proton pump inhibitor; used to treat stomach hyperacidity due to GERD, ulcers, and Zollinger-Ellison syndrome)

Levothyroxine [Sala A, Labrador-Horrillo M, Guilarte M, Luengo O, Rueda M, Cardona V. Immediate-type hypersensitivity reaction to levothyroxine and desensitization. Ann Allergy Asthma Immunol. 2008; 100:513–4.] (synthetic thyroid hormone)

Loperamide [Srinivasa MR, Phelan C. Death due to anaphylactic shock after ingestion of Imodium instants (loperamide). Allergy. 2007; 62:965–6.] (brand name: Imodium®; used to treat diarrhea)

Lysophilzed alpha-chymotrypsin [Watson PG. Anaphylactic reaction caused by intramuscular injection of lyophilized alpha-chymotrypsin. Br J Ophthalmol. 1964; 48:35–8] (with intramuscular injection)

Methotrexate [Goldberg NH, Romolo JL, Austin EH, Drake J, Rosenberg SA. Anaphylactoid type reactions in two patients receiving high dose intravenous methotrexate. Cancer. 1978; 41:52–5.] (high dose, intravenous)

Muscle relaxants [Fisher MM, Munro I. Life-threatening anaphylactoid reactions to muscle relaxants. Anesth Analg .1983; 62:559–64.]

Omeprazole [Confino-Cohen R, Goldberg A. Anaphylaxis to omeprazole: Diagnosis and desensitization protocol. Ann Allergy Asthma Immunol. 2006; 96:33–6.] (proton pump inhibitor; brand name: Prilosec®)

Paclitaxel [Prieto Garcia A, Pineda de la Losa F. Immunoglobulin E-mediated severe anaphylaxis to paclitaxel. J Investig Allergol Clin Immunol. 2010; 20:170–1.] (used to treat cancer)

Pantoprazole [Vovolis V, Koutsostathis N, Stefanaki E. IgE-mediated anaphylaxis to proton pump inhibitors - cross-reacting study. Allergy. 2008; 63:1251–2.] (proton pump inhibitor; brand names include Somac, Pantoloc, Protium, Pantecta, Protonix, and Pantoheal)

Protamine [Nybo M, Madsen JS. Serious anaphylactic reactions due to protamine sulfate: A systematic literature review. Basic Clin Pharmacol Toxicol. 2008; 103:192–6.] (used to reverse anticoagulant effects of heparin)

Rabeprazole [Vovolis V, Christogianni K, Koutsostathis N. IgE-mediated anaphylaxis to rabeprazole. J Investig Allergol Clin Immunol. 2010; 20:360–1.] (proton pump inhibitor; brand name: Aciphex®)

Ranitidine [Walker AI, Werfel S, Kick G, Przybilla B. Repeated anaphylactic responses induced by oral challenge with ranitidine. Acta Derm Venereol. 2010; 90:189.] (H2 antihistamine; brand name: Zantac®)

Terconazole [New safety information regarding the risk of anaphylaxis and Toxic Epidermal Necrolysis (TEN) associated with TERAZOL® 7 Vaginal Cream 0.4% (terconazole); TERAZOL®3 Dual-Pak®- Vaginal Cream 0.8%/Vaginal Ovules 80 mg (terconazole).] (treats fungal and yeast infections of the vagina; brand names: Terazol®; 7 Vaginal Cream 0.4%; TERAZOL® 3 Dual-Pak®- Vaginal Cream 0.8%/Vaginal Ovules 80 mg)

Triamcinolone [Karsh J, Yang WH. An anaphylactic reaction to intra-articular triamcinolone: a case report and review of the literature. Ann Allergy Asthma Immunol. 2003; 90:254–8.] (injected corticosteroid)

Tubersol skin test [Tubersol and anaphylaxis. Cmaj 2004; 171:994.] (Tuberculin Purified Protein Derivative [Mantoux])


Nuts and seeds

Acorns and chestnuts [Zapatero L, Baeza ML, et al. Anaphylaxis by fruits of the Fagaceae family: Acorn and chestnut. Allergy. 2005; 60:1542. ] (members of the Fagaceae family)

Brazil nut [Borja JM, Bartolome B, Gomez E, et al. Anaphylaxis from Brazil nut. Allergy. 1999; 54:1007–8.]

Cashew nuts [Hasegawa M, Inomata N, Yamazaki H, Morita A, Kirino M, Ikezawa Z. Clinical features of four cases with cashew nut allergy and cross-reactivity between cashew nut and pistachio. Allergol Int. 2009;58(2):209-15.]

Hazelnut [Flinterman AE, Akkerdaas JH, Knulst AC, et al. Hazelnut allergy: From pollen-associated mild allergy to severe anaphylactic reactions. Curr Opin Allergy Clin Immunol. 2008; 8:261–5]

Millet seeds [Parker JL, Yunginger JW, Swedlund HA. Anaphylaxis after ingestion of millet seeds. J Allergy Clin Immunol 1981; 67:78–80.]

Psyllium seed husks [Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990; 323:1072–3.] (a natural laxative)

Pumpkin seeds [La Shell MS, Otto HF, Whisman BA, et al. Allergy to pumpkin and cross-reactivity to pollens and other foods. Ann Allergy Asthma Immunol. 2010; 104(2):178–180.]

Sesame seeds [Malish D, Glovsky MM, et al. Anaphylaxis after sesame seed ingestion. J Allergy Clin Immunol. 1981; 67:35–8.]

Sunflower seeds [Yagami A. Anaphylaxis to lipid transfer protein from sunflower seeds. Allergy. 2010.]

Tangerine seeds [Wang ET. Anaphylaxis caused by tangerine seeds but not tangerine fruit. Ann Allergy Asthma. Immunol. 2008; 101:553–4.]


Photograph by Randy/ak37, taken on January 2, 2006, using a Canon PowerShot A95.

Photo by Randy/ak37

Bonsai [Plebani M, Borghesan F, Burlina A. Bonsai: A new allergenic source. J Allergy Clin Immunol. 1994; 94:561.]

Chymopapain [Smith MB, Hofmann VC. Anaphylactoid reaction to chymopapain. Anaesthesia. 1989; 44:767–9.] (enzyme isolated from the latex of the papaya plant that is used to treat herniated lumbar disks)

Hydrolyzed wheat protein [Fukutomi Y, Itagaki Y, Taniguchi M, et al. Rhinoconjunctival sensitization to hydrolyzed wheat protein in facial soap can induce wheat-dependent exercise-induced anaphylaxis. J Allergy Clin Immunol. 2011; 127:531–3.e3.] (in soap, induced wheat-dependent exercise-induced anaphylaxis)

Lupin [Campbell C, Jackson A, Johnson A, Thomas P, Yates D. Occupational sensitization to lupin in the workplace: Occupational asthma, rhinitis, and work-aggravated asthma. J Allergy Clin Immunol. 2007; 119:1133–9.] (a legume)

Natural rubber latex [Lieberman P. Anaphylactic reactions during surgical and medical procedures. J Allergy Clin Immunol. 2002; 110:S64–9.] (milky substance collected from Hevea brasiliensis trees

Orchard grass [Tsunoda K, Ninomiya K, Hozaki F, Kimitaka Kaga. Anaphylaxis in a child playing in tall grass. Allergy. 2003; 58(9):955–6.] (inhaled)

Papain [Bernstein DI, Gallagher JS, Grad M, Bernstein IL. Local ocular anaphylaxis to papain enzyme contained in a contact lens cleansing solution. J Allergy Clin Immunol 1984; 74:258-60.] (enzyme from papaya that is used in contact lens cleansing solutions)

Poinsettia [Kimata H. Anaphylaxis by poinsettia in infants with atopic eczema. Allergy. 2007; 62:91–2.] (Euphorbia pulcherrima)

Skin abrasions [Spitalny KC, Farnham JE, Witherell LE, Vogt RL, Fox RC, Kaliner M, et al. Alpine slide anaphylaxis. N Engl J Med. 1984; 310:1034-7.] (during pollen season)

Soy protein, inhaled [Burches E, Cervera R, Pelaez A. Food-induced anaphylaxis caused by inhalation of soy protein. J Investig Allergol Clin Immunol. 2007; 17:413–23.]



Page last updated: July 1, 2014

All information contained in this site is one layperson's interpretation of medical journal articles, textbooks, seminars, presentations, and other materials. Nothing that is stated here should carry more weight than the informed and considered opinions of your own highly trained and qualified medical caregivers. The author of this site is not a doctor and has absolutely no authority to prescribe or diagnose.

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